REVIEW ON ANOGEISSUS LEIOCARPUS A POTENT AFRICAN TRADITIONAL DRUG. Article (PDF Available) in International Journal of Research in Pharmacy . Common Name: African Birch. Anogeissus leiocarpa. Close-up of the flowers. Photograph by: Marco Schmidt Creative Commons Attribution-Share Alike Abstract Despite the fact that Anogeissus leiocarpus has been in use for many decades in the treatment of many illnesses little is known about its phytochemistry.

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Anogeissus leiocarpa

Support Center Support Center. Associated Data Supplementary Materials mediciness The following are available online at www. Received Aug 27; Accepted Sep Concentration of alkaloids, tannins, steroids, flavonoids and phenols were Botanical identity was assessed by Dr. The acute inflammatory response and its regulation.

Host Inflammatory Response to Infection in Helicobacter pylori: Influence of polyphenols on bacterial biofilm formation and quorum-sensing. Many studies have demonstrated the antimicrobial; anti-carries, anti periopathic and antifungal properties of both aqueous and ethanolic extract s of various chewing sticks Akande and Hayashi, Anogeissus leiocarpus has been shown to be active as antimicrobial agent against gram-positive and gram-negative bacteria such as Pseudomonas aeruginosaStaphylococcus aureus Machido and Ado, ; Taiwo et al.

Due to its extensive arsenal of virulence factors and inherent resistance to antibiotics, Pseudomonas aeruginosa is a threat particularly in immunocompromised patients. The inner bark of the tree is used as a human and livestock antihelmintic for treating worms and for treatment of a couple of protozoan diseases in animals, Nagana an animal trypanosomiasis and Babesiosis Bohm and Koupai-Abyazani, An ethnopharmacological survey and in vitro confirmation of ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana.


Anthelminthic efficacy of some plants used in ethnoveterinary practices in the Arid zone of North Eastern Nigeia. Evaluation of malian traditional medicines: Curbing inflammation in burn patients. Production of virulence factors by P.

Hand book of Nonprescription Drugs. Additionally, the anti-QS activity also preserves a minimal ROS level as it reduces virulence factor production such as pyocyanin, and more importantly reduce the abilities of leipcarpus to degrade host tissue and to resist host immune responses that can maintain inflammation and delay the healing process.

Total polyphenol and total anogeissua were quantified from methanol extract of A. Please share your Comments.

In vitro trypanocidal effect of methanolic extract of some Nigerian savannah plants.

Inhibition of pyocyanin production was assessed according to previously described procedures [ 27 ]. Inhibition of violacein production in C. The mechanism by which pyocyanin causes cell cycle arrest is related to its redox oxidation—reduction properties, and its ability to reduce molecular oxygen into reactive oxygen species induces low-level, yet persistent, oxidative stress [ 4041 ].

Conflicts of Interest The authors declare no conflict of interest.

anogeissus leiocarpus bark extract

However, this study found tannin in the bark extract to be lesser in concentration List of plasmids used in this study. Saponins found in beans interfere with the replication of cell DNA thereby preventing the multiplication of cancer cells. Anti-Quorum Sensing Activity To assess the ability of the methanol extract from A leiocarpus stem bark to interfere with the quorum sensing mechanism, the reporter strain C. Determination of serum alkaline phosphatase activity, total and direct biluribin were conducted as described by Chawla The authors declare no conflict of interest.


Formation of complexes between protein and tannic acid. Hence, the reduction of pyocyanin production recorded within 18 h was not the consequence of any bactericidal or bacteriostatic effect but probably the effect of some interference with the QS mechanism of P.

Medicinal Plants and Traditional Medicine in Africa. Steroids were found to be In traditional medicine, many ailments of livestock and man, such as helminthosis, schistosomiasis, leprosy, diarrhea and psoriasis are treated by the plant parts Burkill, ; Ibrahim et al.

Anogeissus leiocarpa – Wikipedia

Antifungal and antioxidant activities of 14 plants used in the treatment of sexually transmitted infections. Total polyphenol was determined according to the colorimetric method of Folin—Ciocalteu [ 24 ]. Many Combretaceae species are widely distributed in Nigeria and anogeissuw used in traditional medicine for treatment of respiratory diseases asthma, catarrh, chronic bronchitis, cough, hay-fever, hemoptysis, pneumonia, pulmonary disorders and tuberculosis Mann et al.

Taken together, anti-QS and antioxidant activities of A. The antiplasmodial activity of Anogeissus leiocarpus and its effect on oxidative stress and lipid profile in mice infected with Plasmodium bergheii. The flavonoids catechin, isolated from Combretum albiflorum and naringenin have been reported to inhibit QS-regulated virulence factors expression in P.