APOPTOSIS VA INTRINSECA Y EXTRINSECA PDF

En las celulas mamiferas, la apoptosis es mediada por dos vias: una ruta extrinseca de receptor de muerte y una ruta intrinseca mitocondrial. La via extrinseca. Explicar la conformación de la pleura indicando su función y drenaje. BIBLIOGRAFÍA: . Via intrinseca y extrinseca de la apoptosis. Enviado por. Apoptosis, mecanismo de acción. Jorge Pérez Machado,1 Alejandro Eliécer Lie Concepción2. Diana Valentina Moreno. Juan Sebastian Hernandez. MEDICINA .

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Vilma Maldonado Lagunas Dr. Esto coincide con papers previos en los que los niveles relativos de IKK1 y 2 determinaban la activacion de NFkB y un articulo previo de IKK1 como inhibidor en macrofagos.

En el caso del TIMP seria interesante analizar los niveles de ambas. Este articulo es interesante. Este es el corte de p65 por caspasa 3. Papilomavirus induce la expresion de IAP Podria ser un marcador? E6 from HPV16 and 18 played a major role in the activation. In addition, the induction of c-IAP2 transcription required nuclear factor- B activity. Wednesday, July 27, Elemento faltante. Este es un articulo importante.

Sin embargo qpoptosis existian las contrapartes de las caspasas de la via extrinseca. Algunos pensaban que la modulacion era mediada solo por FLIP, una proteina parecida a c.

Las CARP habian sido identificadas antes como RHF1, un gen que estaba sobreexpresado en cancer de esofago, pero para el que no tenian funcion esto no viene en el articulo. Ya tenemos primers de CARP1, que funcionan bien.

Suppression of caspase and associated RING proteins results in sensitization to extrihseca ligands and inhibition of tumor cell growth. Furthermore, CARPs are rapidly cleaved during apoptosis. However, in tumors and tumor cell lines, they are overexpressed, and their silencing leads to restoration of efficient apoptosis via enhanced activation of DED caspases.

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Muerte celular programada en protozoarios: el caso de Giardia intestinalis.

Long-term inhibition of CARP expression results in suppression of cancer cell growth, highlighting their importance in tumor cell survival. Tuesday, July 26, Revision de apoptosis intrinseca. For more than a decade, it has been apparent that apoptosis and other forms of cell death are often controlled at one or more crucial steps involving the mitochondria.

Recent findings, including an elegant investigation in a recent issue of Cell Hao et al. The emerging, if preliminary, perspective these new studies provide may represent either a refinement of our views of how cells die or, perhaps, the beginnings of what amounts to a reformulation of our ideas. Me gustaria que todos lo leyeran, sobre todo por nuestro resultados de smac y lo que planeo hacer a continuacion. Revision de checkpoint mitotico. The new study shows that one type, MMP-3, causes normal cells to express a protein, Rac1b, that has previously intrinsecq found only in cancers.

Laboratorio Biologia Molecular: July

Rac1b stimulates the production of highly reactive oxygen molecules, which promote extrinsecca in two ways — by leading to tissue disorganization and by damaging genomic Exhrinseca. Changes in the cell skeleton induced by Rac1b trigger the formation of extremely reactive molecules known as reactive oxygen species, or ROS.

In turn, the increased amount of ROS activates key genes that control the epithelial-mesenchymal transition — the first slippage in an avalanche of tissue disorganization. Littlepage, Hong Liu, Celeste M.

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Fata, Devin Leake, Elizabeth L. Bissell, appears in the 7 July issue of Nature. Interesante por el hecho de que la modificacion externa, mediada por el estroma, puede incidir en la progresion del cancer.

Cubre un vacio en el papel de la estromelisina en el cancer de mama. Friday, July 22, Caspase-independent cell death.

Una nueva revision publicada en Nature Medicine 11- de G. Kroemer el de AIF Caspase activation has been frequently intrinzeca as synonymous with apoptotic cell death; however, caspases can also contribute to processes that do not culminate in cell demise. Moreover, inhibition of caspases can have cytoprotective effects.

Biologia Molecular de la Apoptosis by marlon hernandez on Prezi

In a number of different models, caspase inhibition does not maintain cellular viability and instead shifts intrinsea morphology of death from apoptosis to nonapoptotic pathways. Here, we explore the contribution of caspases to cell death, either as upstream signals or as downstream effectors contributing to apoptotic morphology, as well as alternative strategies for cell death inhibition. Este es nuestro blog. Pueden realizar todo tipo de comentarios, avisos, quejas, etc.

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