Hyper-CVAD regimen for NHL and ALL: Part A: Cyclophosphamide, Vincristine, Doxorubicin, Dexamethasone. Contact Physician. HYPERCVAD Regimen. Cyclophosphamide-Vincristine-Doxorubicin- Dexamethasone-Methotrexate-Leucovorin-. Cytarabine. Disease Site. Modification of the hyper-CVAD regimen with anthracycline intensification did not improve outcome. Other modifications of the program could include.

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If you’re struggling to find what you need, call our Support line lrotocol Monday to Friday, 9am-8pm. It is best to read this information with our general information about chemotherapy and the type of cancer you have. Hyper-CVAD is usually given into a vein and as tablets.

You usually have it during a hospital stay or as an outpatient. Your cancer doctor or nurse will tell you how often you will have it. Hyper-CVAD can cause side effects.

Some of the side effects can be serious, so it is important to read the detailed information below. Your healthcare team can give you advice on how to manage any side effects. Tell your doctor or nurse straight away if you:.


Rarely, side effects may be life-threatening. Your cancer doctor or nurse can explain the risk of these side effects to you. If you need medical attention for any reason other than cancer, always tell the healthcare staff that you are having this treatment. Hyper is short for hyperfractionated. It means you are given more than one treatment of the same drug in a day.

CVAD stands for the initials of some of the drugs used:. But most people call it hyper-CVAD as it is easier to say and write down. You will be given hyper-CVAD during a stay in hospital or in the chemotherapy day unit. A cvsd nurse will give it to you. During treatment, you usually see a cancer doctor, a blood specialist haematologista chemotherapy nurse or a specialist nurse. This is who we gyper when we mention doctor or nurse in this information.

Before or on the day of treatment, a nurse or ccad trained to take blood phlebotomist will take a blood sample from you. This is to check that your blood cells are at a safe level to have chemotherapy.

You will see a doctor or nurse before you have chemotherapy. They will ask you how you hypdr been feeling. If your blood results are okay, the pharmacist will prepare your chemotherapy.

Your nurse will tell you when your treatment is likely to be ready. Your nurse usually gives you anti-sickness anti-emetic drugs before the chemotherapy. The chemotherapy drugs can be given through:. The nurse will give you the chemotherapy drugs separately into your line. They run your drip infusion through a pump, which gives you the treatment over a set time:.


Sometimes methotrexate and cytarabine are given by injection into the fluid around the spinal cord intrathecally. Watch our short animated videos about having PICC cvwd and central lines put in. You have chemotherapy as a course of several sessions cycles of treatment over a few months.

You will have each schedule four times in a pattern of A then B. Each cycle of hyper-CVAD lasts 21 days. But if you have hyper-CVAD before a stem cell transplant, you cvsd only have two cycles of each schedule.

Day 1 — your nurse gives you two separate drips of cyclophosphamide. The second drip pgotocol given 12 hours after the first. You will be given fluids through a drip before and after cyclophosphamide. You also start taking dexamethasone steroid tablets. You take them for prtoocol days days 1 to 4. Protocpl 2 — you have two drips of cyclophosphamide again. They are given 12 hours apart. Day 4 — you have vincristine and doxorubicin as a drip.

You can usually go home the day after it finishes.

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Day 11 — you have vincristine again, usually in the chemotherapy day unit. You also start taking dexamethasone tablets for four days days 11 to This is the last week in the cycle of hyper-CVAD. Your next cycle will be Schedule B. Day 2 — you usually have a drug called leucovorin folinic acid as a drip to reduce the side effects of methotrexate.

You have it regularly until the methotrexate is out of your system. You also have two drips of cytarabine. Day 3 — you have two more drips of cytarabine.

You can usually go home after this if your methotrexate levels are okay. This completes another cycle of hyper-CVAD. Your next cycle will be schedule A again. Some people jyper methotrexate and cytarabine given into the spinal fluid called intrathecal chemotherapy. Your cancer doctor or nurse will tell you more about this.

You usually have it on different yyper from the rest of your chemotherapy treatment. The doctor numbs an area of skin over your spine with local anaesthetic. They gently insert a needle between two of the spinal bones.

This is called a lumbar protoccol. They inject the chemotherapy drug through this needle into the spinal fluid. Before you go home, the nurse or pharmacist will give you anti-sickness drugs to take. You may also be given other drugs to protockl, for example to help reduce your risk of getting an infection. Take all your tablets exactly as they have explained to you.

We explain the most common side effects of this treatment here. We also include some less common side effects. You may get some of the side effects we mention, but you are unlikely to hpyer all of them.


Always tell your doctor, nurse or pharmacist about any side effects you have. Your doctor can give you drugs to help control some side effects. It is important to take them exactly as your nurse or pharmacist explains. This means they will be more likely to work for you.

Your nurse will give you advice about managing your side effects.

After your treatment is over, most side effects start to improve. Some cancer treatments can cause severe side effects. Rarely, these may be life-threatening. Your nurse will give you telephone numbers for the hospital. If you feel unwell or need advice, you can call them at any time of the day or night. Save these numbers in your phone or keep them somewhere safe. We cannot list every side effect for this treatment. There are some rare side effects that are not listed.

Hyper-CVAD – Wikipedia

The leaflet lists all known side effects. Some people may have side effects while hyped are being given the chemotherapy or shortly after they have it:. Some people have an allergic reaction while having this treatment. Signs of a reaction can include:.

Your nurse will check you for signs of a reaction during your treatment. If you feel unwell or have any of these signs, tell them straight away.

Hyper-CVAD chemotherapy – Macmillan Cancer Support

If you do have a reaction, it can be treated quickly. Sometimes a gyper can happen a few hours after treatment. If you get any signs or feel unwell after you get home, contact the hospital straight away. If this happens it can damage the tissue around the vein. This is called extravasation. Tell your nurse straight away if you have any stinging, pain, redness or swelling around the vein.

If you get any of these symptoms after you get home, contact the doctor or nurse straight away on the number they gave you. You may suddenly feel warm and your face may get cvar while the doxorubicin is being given. This should only last a few minutes. Some people may have hot flushes, a feeling of having a blocked nose and a strange taste when cyclophosphamide is being given.

But if you notice this, ask the nurse to slow down the drip, which will reduce these symptoms.