In cases of acute intoxication with propane butane (due to damage in heating appliances where propane-butane is used as energy source for heating), asphyxia. Butane is an organic compound with the formula C4H10 that is an alkane with four carbon . It enters the blood supply and within seconds produces intoxication. Butane is the most commonly misused volatile substance in the UK, and was the. Butane is a commonly misused volatile agent, and a cause of intoxication. We present a case, who had a syncope and persistent ventricular.
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Clin Toxicol Phila ; BeH 2 covalent metal hydride Right: Shugaev exposed rats sex and strain not specified to varying concentrations of butane for 4 h. Third, the use of an intraspecies factor of 3 would lead to AEGL-1 intoxxication that are unrealistically low e.
Although the study was performed with small groups of volunteers 3 or 6 people of a relatively young age yearsan intraspecies uncertainty of 1 is considered adequate for the following reasons.
The reported data LC 16LC 50and LC 84 indicate inotxication the concentration-response curve for a 2-h exposure in mice and a 4-h exposure in rats are very similar see Table Most reports of butane intoxication are from cases of butane abuse or suicide attempts.
ACUTE PROPANE-BUTANE INTOXICATION – Diseases of Poultry – The Poultry Site
Several case reports of intentional butane exposure indicate that butane induces neurotoxicity. Turn recording back on. Lithium hydride, LiH ionic metal hydride Beryllium hydride Left gas phase: Hydroxylation of aliphatic compounds by liver microsomes, I.
National Board of Fire Underwriters; Butane is a gas at room temperature and atmospheric pressure.
Butane – Drug and Alcohol Information and Support in Ireland –
How to cite this URL: Carbon tetrachloride as a toxicological model. Summary A number of fatal and nonfatal cases related to butane abuse or suicide attempts have been described.
The different exposure duration for the two species was based on a comparison intoxicaion the ratio of minute ventilation volume of gas exchanged from the lungs per minute to body weight, which is approximately two-fold greater in mice.
Withdrawal symptoms intoxocation continue for a number of days when use ceases. The AEGL-1 values for butane are based on observations in a study with volunteers on the warning properties of short exposures to butane Patty and Yant Surviving mice recovered rapidly, within 5 min after exposure ended Stoughton butanne Lamson Because of these limitations, no clear conclusions can be drawn.
The study by Stoughton and Lamson provides a no-observedadverse-effect level for lethality in mice exposed to butane for 2 h. Severe encephalopathy was observed in a year-old girl as the result of butane abuse.
About alcohol What is alcohol? Six dogs were exposed to butane for various durations to study its potency as a cardiac sensitizer Chenoweth Because human data are lacking, the AEGL-2 values are based on animal data.
Butane intoxication–three case reports.
On admission to the hospital, there was no spontaneous respiration; an electrocardiogram showed sinus tachycardia with marked T-wave inversion in the anterolateral leads. LC 16 ratio was 1. Because it is easily accessible, butane is often used in inhalant abuse. However, it might be an indication that mice are more susceptible to butane toxicity, because a steady state is expected to be reached rapidly with butane see Intoxiccation 6.
In this way, butane leaks can easily be identified. Guinea pigs exposed for 5 min at 50, ppm showed no significant effects.
Further, a larger factor would lead to unrealistically low values that would be similar to the AEGL-2 values. Butane is produced from raw natural gas and from petroleum streams obtained by catalytic cracking, catalytic reforming, and other refining processes. Inhalation of butane can cause euphoriadrowsinessunconsciousnessasphyxiacardiac arrhythmiafluctuations in blood pressure and temporary memory loss, when abused directly from a highly pressurized container, and can result in death from asphyxiation and ventricular fibrillation.
Ihtoxication propaneputane poisoning [in German] pp.